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Basic Pharmacokinetics
2nd Edition
by Jambhekar, Sunil S; Breen, Philip J
Paperback Book (496 Pages)
March 2012
Basic Pharmacokinetics provides an understanding of the principles of pharmacokinetics and biopharmaceutics. It addresses clearly and concisely how these principles can be applied to achieve successful drug therapy. The applications of principles and equations are illustrated with related problem sets and problem solving exercises.

Features include:
•the use of profiles (sketches of relationships among pharmacokinetic variables and parameters)
•learning objectives
•complete review of mathematical tools required to practice pharmacokinetics.

This new edition has been revised and updated to include:
•new chapters on metabolite pharmacokinetics and pharmacokinetic data fitting
•expanded question data base to include multiple choice questions and true/false questions
•a large increase in the number of questions based on pharmacokinetic profiles.

Basic Pharmacokinetics is an invaluable textbook for undergraduate and graduate students in pharmacy, medicine, and the pharmaceutical sciences. It enables the reader to become adept at solving pharmacokinetic problems arising in drug therapy and to understand the applications and utility of equations in clinical practice.

1. Introduction and Overview

2. Mathematical Review

3. Intravenous Bolus Administration (One-compartment Model)

4. Clearance Concepts

Problem Set 1

5. Drug Absorption From the Gastrointestinal Tract

6. Extravascular Routes of Drug Administration

Problem Set 2

7. Bioavilability/bioequivalence

Problem Set 3

8. Factors Affecting Drug Absorption: Physicochemical Factors

9. Gastrointestinal Absorption: Role of the Dosage Form

10. Continuous Intravenous Infusion (One-compartment Model)

Problem Set 4

11. Multiple Dosing: Intravenous Bolus Administration

12. Multiple Dosing: Extravascular Routes of Drug Administration

Problem Set 5

13. Two-compartment Model

Problem Set 6

14. Multiple Intermittent Infusions

Problem Set 7

15. Nonlinear Pharmacokinetics

Problem Set 8

16. Drug Interactions

Problem Set 9

17. Pharmacokinetic and Pharmacodynamic Relationships

Problem Set 10

18. Metabolite Pharmacokinetics

19. Pharmacokinetic Data Fitting

20. Pharmacokinetics and Pharmacodynamics of Biotechnology Drugs

Appendix: Statistical Moment Theory in Pharmacokinetics
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