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Autophagy of the Nervous System
Cellular Self-Digestion in Neurons and Neurological Diseases
by Zhenyu Yue
Hardback Book (400 Pages)
November 2012
What is autophagy? Why would neurons or other brain cells digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as a culprit or accomplice to cell death in others? How does dysfunction of autophagy contribute to neurological diseases and can it be repaired or restored? This book addresses these questions and provides an expert view of the emerging concepts in autophagy research, focusing on autophagic processes and regulation in neurons. Current experimental evidence for both evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented. Advances in our understanding of the complex interplay of autophagy induction and downregulation will be discussed in relation to the critical balance needed to modulate neuroprotection versus neurodegeneration in the context of neurological diseases including Alzheimer's, Parkinson's, Huntington's, ischemic-hypoxic and lysosomal diseases.
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•Neuronal Autophagy: Cellular Process and Regulation: ◦The Cellular Process of Autophagy and Control of Autophagy in Neurons (Nicole C McKnight, Noboru Mizushima & Zhenyu Yue)
◦Autophagosome Maturation, Endocytosis and Neurodegenerative Disease (Anne Simonsen & Ai Yamamoto)
◦Cross-Talk Between the Ubiquitin-Proteasome System and Macroautophagy (Serhiy Pankiv & Terje Johansen)
◦Chaperone Mediated Autophagy (CMA) in Neurons (Maria Xilouri, Hsiao-Yu Peng & Leonidas Stefanis)
◦Maintaining Autophagic Balance: A Role for Brakes (Salvatore J Cherra III & Charleen T Chu)

•Autophagy and Neurological Diseases: ◦Autophagy and Its Cross-Talk with Cell Death in Neural Development (Sabrina Di Bartolomeo & Francesco Cecconi)
◦Autophagy in the Retina: Development, Physiology and Pathology (Patricia Boya)
◦Genetic Mouse Models for Elucidation of Autophagy-Lysosomal Systems in Neurons Under Physiologic and Pathologic Conditions (Masaaki Komatsu, Masato Koike, Yoshinobu Ichimura & Yasuo Uchiyama)
◦Autophagy in Amyotrophic Lateral Sclerosis (Jozsef Gal & Haining Zhu)
◦Autophagy Failure in Alzheimer's Disease and Lysosomal Storage Disorders: A Common Pathway to Neurodegeneration (Devin M Wolfe & Ralph Nixon)
◦Autophagy in Huntington's and Parkinson's Diseases: Pathogenic Mechanism and Therapeutic Potentials (Junghyun Lim, Lauren Friedman, Nicole C McKnight & Zhenyu Yue)
◦Metabolism, Autophagy and Neurodegeneration (W Haung Yu & Karen E Duff)
◦The Potential of Autophagy Regulation in the Treatment of Neurodegenerative Diseases (Ashley R Winslow, Zeyn W Green-Thompson & David C Rubinsztein)
◦Lysosome Storage Disorders on the Brain: The Autophagy Lysosome Pathway Contributes to Disease Pathophysiology and May be Utilized for Therapeutic Benefit (John J Shacka)

•Specialized Autophagy: The New Frontier: ◦Autophagy — Roles in Synaptic Structure and Function (Daniela Hernandez & David Sulzer)
◦Axon Trafficking and Autophagy of Mitochondria (Mitophagy) in Neuronal Health and Disease (Charleen T Chu & Zuhang Sheng)
◦Role of Autophagy in Neurite Degeneration In Vitro (Yi Yang, Xiaoxiang Zheng & Tatsuro Koike)

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