To reduce transfusion-related morbidity and mortality, it is recommended that an integrated approach to blood management is employed using all available tools to reduce a patient's exposure to donor blood. Meeting the need for a book covering the concepts of blood management as a trend towards multidisciplinary blood management, this new edition is an important resource, providing healthcare professionals with a tool to develop background knowledge in blood management, its organization, methods and tools. Practicing clinicians will be fully prepared to successfully start and run blood management programs. Preface, vii

Preface to the First Edition, viii

1 History and Organization of Blood Management, 1

2 Physiology of Anemia and Oxygen Transport, 9

3 Anemia Therapy I: Erythropoiesis-Stimulating Agents, 21

4 Anemia Therapy II: Hematinics, 36

5 Growth Factors, 51

6 Fluid Management, 67

7 Chemistry of Hemostasis, 81

8 Recombinant Blood Products, 100

9 Artificial Blood, 109

10 Oxygen Therapy, 124

11 Preparation of the Patient for Surgery, 139

12 Iatrogenic Blood Loss, 160

13 Physical Methods of Hemostasis, 173

14 Anesthesia—More than Sleeping, 191

15 Use of Autologous Blood, 201

16 Cell Salvage, 212

17 Blood-Derived Pharmaceuticals, 229

18 Transfusion Medicine, 245

19 Step by Step to an Organized Blood Management Program, 262

20 Law, Ethics, Religion, and Blood Management, 285

Appendix A: Detailed Information, 297

Appendix B: Sources of Information for Blood Management, 305

Appendix C: Program Tools and Forms, 309

Appendix D: Teaching Aids: Research and Projects, 323

Index, 327
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