Immunology: A Short Course, Seventh Edition introduces all the critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs.

This new edition of Immunology: A Short Course:
• Has been fully revised and updated, with a brand new art program to help reinforce learning
• Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area
• Highlights important therapeutic successes resulting from targeted antibody therapies
• Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical applications
About the Authors xv

Contributors xvi

Preface and Acknowledgments xvii

How to Use Your Textbook xix

About the Companion Website xxiii

1 OVERVIEW OF THE IMMUNE SYSTEM 1

2 INNATE IMMUNITY 11

3 ADAPTIVE IMMUNITY 26

4 IMMUNOGENS AND ANTIGENS 35

5 ANTIBODY STRUCTURE AND FUNCTION 47

6 ANTIGEN–ANTIBODY INTERACTIONS IMMUNE ASSAYS AND EXPERIMENTAL SYSTEMS 67

7 THE GENETIC BASIS OF ANTIBODY STRUCTURE 88

8 BIOLOGY OF THE B LYMPHOCYTE 100

9 HOW T CELLS RECOGNIZE ANTIGEN: THE ROLE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX 117

10 BIOLOGY OF THE T LYMPHOCYTE 137

11 ACTIVATION AND FUNCTION OF T CELLS 153

12 CYTOKINES 176

13 TOLERANCE AND AUTOIMMUNITY 194

14 COMPLEMENT 217

15 HYPERSENSITIVITY: TYPE I 233

16 HYPERSENSITIVITY: TYPES II AND III 249

17 HYPERSENSITIVITY: TYPE IV 259

18 IMMUNODEFICIENCY DISORDERS AND NEOPLASIAS OF THE LYMPHOID SYSTEM 268

19 TRANSPLANTATION 298

20 TUMOR IMMUNOLOGY 312

21 RESISTANCE AND IMMUNIZATION TO INFECTIOUS DISEASES 328

Glossary 351

Appendix: Partial List of CD Antigens 378

Index 381
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